LOCUS       XM_041581102            8830 bp    mRNA    linear   VRT 14-MAY-2021
DEFINITION  PREDICTED: Xenopus laevis argonaute 4, RISC catalytic component L
            homeolog (ago4.L), transcript variant X1, mRNA.
ACCESSION   XM_041581102
VERSION     XM_041581102.1
DBLINK      BioProject: PRJNA338693
KEYWORDS    RefSeq.
SOURCE      Xenopus laevis (African clawed frog)
  ORGANISM  Xenopus laevis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Xenopus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_054373.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Xenopus laevis Annotation Release
                                           101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8830
                     /organism="Xenopus laevis"
                     /mol_type="mRNA"
                     /strain="J_2021"
                     /db_xref="taxon:8355"
                     /chromosome="2L"
                     /sex="female"
                     /tissue_type="Erythrocytes"
                     /dev_stage="adult"
                     /collection_date="06-Jul-2016"
                     /collected_by="Jessica Lyons"
     gene            1..8830
                     /gene="ago4.L"
                     /gene_synonym="ago4; argonaute-4; Argonaute4; eif2c4"
                     /note="argonaute 4, RISC catalytic component L homeolog;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 21 ESTs, 19 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 52 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:734630"
                     /db_xref="Xenbase:XB-GENE-1006885"
     CDS             765..3413
                     /gene="ago4.L"
                     /gene_synonym="ago4; argonaute-4; Argonaute4; eif2c4"
                     /codon_start=1
                     /product="protein argonaute-4 isoform X1"
                     /protein_id="XP_041437036.1"
                     /db_xref="GeneID:734630"
                     /db_xref="Xenbase:XB-GENE-1006885"
                     /translation="

MEAVGPGELEMGGGKAEAKRQDISELGPPPTNLFQPPRRPGLGTLGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMPIFGDNQPGYDGKRNMYTAHPLPIGRDRVDLEVTLPGEGKDQTFKVTIQWVSVVSLQLLLEALSGHLSEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPVIEFMCEVLDVQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKLTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQETTQELLYSQEVIQDLCNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELMAIRKACISLEEDYRPGITYIVVQKRHHTRLFCSDKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHSMYFA"

     misc_feature    903..1292
                     /gene="ago4.L"
                     /gene_synonym="ago4; argonaute-4; Argonaute4; eif2c4"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    1323..1475
                     /gene="ago4.L"
                     /gene_synonym="ago4; argonaute-4; Argonaute4; eif2c4"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    1476..1838
                     /gene="ago4.L"
                     /gene_synonym="ago4; argonaute-4; Argonaute4; eif2c4"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1632..1634,1677..1679,1719..1721,1731..1733,
                     1785..1787,1806..1808,1812..1814)
                     /gene="ago4.L"
                     /gene_synonym="ago4; argonaute-4; Argonaute4; eif2c4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1977..3284
                     /gene="ago4.L"
                     /gene_synonym="ago4; argonaute-4; Argonaute4; eif2c4"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(2388..2390,2400..2402,2436..2447,2454..2456,
                     2478..2480,2487..2489,2499..2501,2511..2513)
                     /gene="ago4.L"
                     /gene_synonym="ago4; argonaute-4; Argonaute4; eif2c4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2592..2594,2598..2600,2838..2840,3252..3254)
                     /gene="ago4.L"
                     /gene_synonym="ago4; argonaute-4; Argonaute4; eif2c4"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

cattttctttcattatccacatttttcgacgttttgcatgggcataccctttacttttgacaaaaccagactctgggagttccacaagtctgcacttggcaaaatccctctcagtttcgactatggagagtcgtgtgaaaccatgcagtttccacacgcgacttccagtttaccggcgcacgtcaccttatggaaatacgacactcgcaagtcgcaacccattaccggaaagtgctaacctgcgtattttttaaaagaacttttattatattacaactcagaacaaatccctgaggtgttcaactactgtagggccacgagcgtctttgtttttaagaatgcgtgtcattccccacgaacgatgaaggagctagcacgctcaacccagtgcactacacggtgcgctgttctcctactcgcacgcacaggcttttctgcgcgcccccggatcgcccttagtgcgcgttcccgctccacgcttgatcctcgctcgtagttgcactctcccggtgacgccgccgcttatctgaggctaccgaatagcttgttcgcggtgattgtaagccgagtgcgggcgggatagcctcaaattgagccgcatttacgcggaggctccttttacctcctttttactacacggcgaggcctccgttggtcggtgaggctttccccctcccctggctccgattccgtccttagagagaccccaacccggagcaaatattccggagaaaaagagactcccggagaggacagcagcggagatggaggcggtggggcctggtgagttggagatgggagggggcaaagcggaagcgaaaaggcaggatatctccgagcttggccctccaccgactaacctcttccagcctccgcggcgtcctggcctgggaacactgggaaagccaattaggctactggccaaccattttcaggttcagatcccgaagatcgatgtctaccattatgatgtggacatcaagccagagaaaaggccaaggagagtcaacagggaggtggtggatacaatggtacgtcatttcaagatgccgatttttggagacaaccagccaggttatgatggtaaaaggaacatgtacactgctcacccactaccaattggcagagacagagttgatttggaagtgacccttcctggtgaaggcaaagaccagactttcaaagtcactattcagtgggtctcggtagtgagtcttcagcttcttttagaggctctctctggacatctaagtgaagttccggatgattctgttcaggcgctagatgtaatcactcgccatctaccatccatgaggtatacaccagttggacggtccttcttctctcctcctgaaggttattatcacccactcggtggtggccgagaagtttggtttggctttcaccagtctgttcgtccagctatgtggaacatgatgctcaatattgatgtttctgcaacagctttttaccgagctcagccggtcatagaatttatgtgtgaagtcctagacgtgcaaaacatcaatgagcaaacaaagcctctgactgattcacagcgtgtcaagttcaccaaagaaataagaggtctgaaagttgaagtgacacactgtggacagatgaaaagaaaatacagagtgtgcaatgttactagaaggccagcaagccaccagacgtttcctttacagttggagaatggtcaagccatggagtgtactgttgctcagtactttaagcagaaatatagcttacaattaaaatatccccatctcccttgcttgcaagttggacaggagcagaaacacacatacttaccacttgaggtttgcaacattgtagctggccaacgatgtattaagaaactgacagacaatcagacttccactatgatcaaagctaccgcccgatctgctccagacagacaggaggagatcagcaggctggtgaagagtaacagtatggttggtggaccagatccgtacctcaaggagtttggcattgttgttcataatgaaatgacagagctaacaggcagagtgttgccagcaccaatgcttcagtatggaggaaggaataaaactgtggccaccccaaaccagggtgtttgggacatgagaggaaagcagttctatgctggtattgagatcaaagtttgggctgttgcttgttttgcaccacagaagcagtgccgagaagacttgttaaagagtttcactgatcagttaagaaagatctccaaagatgcaggaatgcccattcaaggtcagccttgcttctgtaaatatgctcaaggcgctgacagtgtggagccaatgttcaaacatcttaagttgacatatgttggtcttcaacttatcgtggtgattttgcctggcaagactccagtttatgcggaagtgaaacgagtaggagacacgctacttggtatggccacccagtgtgttcaggtgaaaaatgtagtcaagacatctcctcagacactatcaaacctctgcctgaaaatcaatgccaagctagggggaattaacaatgtgttggtgcctcaccaaagaccttcagtgtttcagcagcctgttatatttttgggagctgatgtaacacacccccctgctggggatggcaagaaaccttccattgcagctgtagtgggcagcatggatgggcatcccagccgctactgtgccactgtgcgtgttcagacctcacgccaagagacaacccaagagttgctgtacagccaggaagttattcaagatctttgcaacatggttcgggaactgcttatccagttttacaagtcaactcgctttaaaccaacaagaatcatctactatagaggaggcgtttctgaaggtcaaatgaaacaggtggcatggccagagcttatggcaattcgaaaggcctgcatcagcttggaagaagattacagacctggaataacctacattgttgtacaaaagaggcatcatacaaggcttttttgctctgataaaacagaaagggttggaaagagtggcaatgtgccagcaggaactacagtggacagcacaataacacacccatcagaatttgatttctatctctgtagtcatgctgggattcagggaacaagtcgtccatctcattaccaggttctctgggatgataactgcttcactgctgatgaactccagctactaacctaccagctgtgtcacacatatgtgcggtgcacgcggtctgtttcaatccccgcccctgcttactatgctcgactggttgcattcagagcaaggtatcatcttgtagataaggatcatgacagtgctgaaggaagccatgtatctggtcagagcaatggtcgagatcctcaagctctggccaaagctgttcagattcaccacgacacacaacactcaatgtactttgcctgacagcacagtgagaactggcacagactctcctcatccttcttttccaggccctgaagtcttctgttaagcaggcttgcctgtaattttcagggccagttctgtctcttggcttcccaccagcacattttggactttttgcactgaatctctttaccatggcatttgaatggaggaaagatgcaaacctttttatttagttatctcaaaaaacttatggattgtcttctgatgcattggactgaatatttacctcaagctcaaaagatatctgaacattttactccaagcaactcttgttgtgttaattgttttaatttgcaagccagcatttcttcatccttggttgtaacaaaaatgtacatgctttttgtctgaacatgctgctttgcaactgtacttaaatggaaaagtttaactgagtgggccatagacttgctaaatgaggtttagtccttactgtataataacttcttaatgtttttacagataatgccgtctgtcaggttcttaaccattgcaaacttgtactttttaacgagtgcaggctgcaaacctattgcactatattgcatattaattaaggtaagtttttatttctgtataaaatgaatgtgtaatattaagatttaatataagggccatgtggcgagcactgccatatagttttttcacttgcagattgccattacttttccttccccaggcacttttgcttcccaagacaaccgtatgttagtattttgccagcgcacacagacgcccgtgtcaatgctgctgcagtttgataaaagtttttactctcggagggatgggtgtggggtaccatttttatggcaataaaacattttagtatcataacatcatttcaacatccacctggtttttgggtgttgtatggtgtagacttttttctcctttcagtaaaatttgtcaaattgattttacaatcactttttcacatggtttttttttttcctaatggagattgttacttccagtaaaggttatgacctcttgactattctggaacccttggcagagaattctttattgccagcagggcaggccctgcatgtgcaaaaatcaaactcctttacttttgggagagatgtaggcagctttggagggcagagactacacgatttataccagcattttccgtttgtgttggtcctctgaacccagactaacaaagtgcatgtttgtataatttgcatgtacataattttcttattataccttttagtttatcatttttatgaatgaaaactgaaccaattctatatacacatgctctttgctatcctccttgctctctcaactataaaaggtaattgagataaacctttacagtgctctactacatgcaggttttctgatgtagcgactccattaactttaacaagccctgtctttgtttctctggtatacctcagttgcattcactgctttttcctgctctggttatccgtattcttgcagcatgacaacaggtttgaccagcgatttttctttccttctctccatatttacacaaacacagaatatacctcactgggacagtagaagttgtgaacgggaggattattgtgctgctttgggctttattgctgcttggtaacccactttagtgccagaaaggcctcctgaaggtgctacggttgtaatcttttgtaagtagcgtgtttgcagttgcagcttggtgagactctacgtacgaccttgatagctttgcagtgtttggtggtgatttcttcagcagttcaatttcacaataaaattgctggtcgcacataaggcagttttttttgtatgtggcatgccataagttggtccattgtttttttattatttgtatattgtgtaattagattgggtcacaacagaagaacatccttatctctgctttgctgatggctgcatacatttgccagtcacgagccagccaggccttctattttctgtgaccaactcttatataactcccaaatgagattgttggatgtagtcattcagagatatttctagaattgccaagtttggctaaaaattataattgtcagacctgattgttacattatggctagctttaataacaattttacaatagacacgttctttatgaaccttgagtgaggcttctctaaactattttgatagctgatgatttgatagctgcttctgattgcttttgtttagctatgtcatcaacaggcaccggtgagctacagtcccaacattaagcaaatgatgtttctgggagttgtcgttcatacaatatggaggtgtagggttcacatatttgatgcttctgtttagtgctacattgcggtaatgctagtgaagctttggtttagaaacccagtaaggctttaaacccactattaactagcaatatcaagcttttaattcatatgacagacaatgaattatattagtagattattaacctatttaaaatgcagagcaagtgctgaaacatccaaaatgtatgttaacatgaatttcagtcttaatccaagtataacattttaaaactaaaaactgatgaaatttaggtcagtgaaaattgttttgtagctaataaaatgcagacctatgtagttcaccattgtgcaatatgtgaacaaaaacaccatatacattgctaaatccagggtcattgcaaataagtgtaaactgccgacggctattgcttttttctaccacagcataaatagtgtttttagctactttgggttagttgcgatcatcaacagtgttttctatttacatctttcaaggcttgcgcaataagcaacaaataactttgccatgagcttcaatatgcagccgactttattgcagtgtctagctttggccacttgtgattcttacaagggtctacatgcttgtataatgatatcaaactgagccaggatacctacagtttaggagatctgtacagtttgggaagtatgattttgtctttcttatgaccgcaatatcaattttgttttaatttctggttaattgaggataaagggacatgggagggagggtaagcattaggtagaggtgggtgtatgtgttttgtaaacttttaaaacactgcacagtttgtgttgcagcaatactattgtgaactgtttttgactttattttttttccctagtaaatagcagggggtgtgcttggatcagtgttttggggaagatttgtacttgttttaagaggtttgattaacagttgcatattgtttcagtttttctctcattagactttttaaagggaatctgtcggtcatgagtgtttaggaacttgtaaaattgcaaactttttctttttttttctttcttttttttcatttttcctaaatgttactccttaatatgtgtctctctaatctgtattttccgttcttactggcaacaattgtttgtttactgggttcttaaatgaattctaagttccctatgagatctgtagacatttccagttacaatcttttctatacctagtcaacccatgacttgtctgtaagtgtaaaggaaaatgtaatgcaagtgatctgtattaaaatggcccattgttagaattctgtataccatacagtgtaatggaggtacatgtggctttaccacaaagtaggcatacttccagatttaaaaacaaaacaaaaaaaccctcttatactgcagtctgaaactgtgtagtcattttgttttttgtgctataacatttggttttcatggtaagggacatcctacttccaggacggttttgaagaaagcatttcatgtttcaaatgatggattcactttaaactgatctgaagatctaatggatatatctgggtagttggcatactgctggaaactgcgctggaaggatagtctgtgggtgtgggctcccatgattgctggccctcctttattaagtggttgtaatctggaatctctgttagacttccgttcagataagtgaatcaaggtcaagtgagagttgtaggcctctaacaatacttgtaagagcatttgttgcattaaacctgcacattggcataacctgaatgaatgcaacagcctgcttagtgtgtgtgggtttatttgcagagtaatctcaaggtaagtttggtctatgtagatagttgtagcataagaattttaactctaacacttgcgctaatgacaatcttacaaaatacactgtcacaggactcaccatttttattgtcctaatcttgtaactgattttcatcaattttaatattttggcataaagaaacattctttcattatctttcagtcaaactataaatcagatttgcagatgcaagactttgcagtgggtcactaagtactccagtctgtattctttttcctctcttttagttatacctaggaaccacttgctcttacatggaaacaatggtagaatgtgtcaaatgtatactttttgctttacagatcccacacttctggttttcatttctaaattgagaagcactttgcccccccccccttccttttttttcgccatggacttatctttttccttgccaagcacataagtctatcttgttggcaaggcagttatcttcccagcaatgaatgtttccccattccagtctgggaaaagcattttatcttgcggtgtgttgttccctaaacatagaaaatggctgatgggggggggagggttaatgaaatcaccaatactcgttcagaggttgcatttgtcgtgagtgactgagctgtacaccctgatttttttttttttcttttatattgcttacccattttattaggaagtactatccaaactactatgagattatgcatatgtgttgggtatttacatatagattacatttacattagtgtccctttagtagtagtaacttccttacactgactctagatttgttagaaattatgtagcagtatacaggcttgcttgaaaagggacaccacctgctttctttgagggcattttaaaaaaaaaaagcttattttggctgattttatgatctgtgtgacatttgaaaagtttactgttatcacttttttaattcccctagcaaataggtataaaataccatgtttccttatttctatagtatttctatgtctaggaatggggattccttgtataaactttgcatttattgaacttttgatgtacatttcttttggtttctatattgtcgctagacttgtaatgtttaaatcgtgttctatgaaattttcagtggatgtatgtctatagcaatacgaggtattttttttctttttttaaaaaaaagctatttaaggatggtttagcagccccaactgctagacctgagatgctggctgtgtaattttttaacttcgcagggatataatttgttttatgtgtctaaaataaaatataaaggcagtatgccaaataaa

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