LOCUS       NM_153472               1334 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus MNAT1 component of CDK activating kinase (Mnat1),
            mRNA.
ACCESSION   NM_153472
VERSION     NM_153472.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1334)
  AUTHORS   Fujii,W., Nishimura,T., Kano,K., Sugiura,K. and Naito,K.
  TITLE     CDK7 and CCNH are components of CDK-activating kinase and are
            required for meiotic progression of pig oocytes
  JOURNAL   Biol Reprod 85 (6), 1124-1132 (2011)
   PUBMED   21778139
REFERENCE   2  (bases 1 to 1334)
  AUTHORS   Egly,J.M. and Coin,F.
  TITLE     A history of TFIIH: two decades of molecular biology on a pivotal
            transcription/repair factor
  JOURNAL   DNA Repair (Amst) 10 (7), 714-721 (2011)
   PUBMED   21592869
  REMARK    Review article
REFERENCE   3  (bases 1 to 1334)
  AUTHORS   Sano,M., Izumi,Y., Helenius,K., Asakura,M., Rossi,D.J., Xie,M.,
            Taffet,G., Hu,L., Pautler,R.G., Wilson,C.R., Boudina,S., Abel,E.D.,
            Taegtmeyer,H., Scaglia,F., Graham,B.H., Kralli,A., Shimizu,N.,
            Tanaka,H., Makela,T.P. and Schneider,M.D.
  TITLE     Menage-a-trois 1 is critical for the transcriptional function of
            PPARgamma coactivator 1
  JOURNAL   Cell Metab 5 (2), 129-142 (2007)
   PUBMED   17276355
REFERENCE   4  (bases 1 to 1334)
  AUTHORS   Sandrock,B. and Egly,J.M.
  TITLE     A yeast four-hybrid system identifies Cdk-activating kinase as a
            regulator of the XPD helicase, a subunit of transcription factor
            IIH
  JOURNAL   J Biol Chem 276 (38), 35328-35333 (2001)
   PUBMED   11445587
REFERENCE   5  (bases 1 to 1334)
  AUTHORS   Busso,D., Keriel,A., Sandrock,B., Poterszman,A., Gileadi,O. and
            Egly,J.M.
  TITLE     Distinct regions of MAT1 regulate cdk7 kinase and TFIIH
            transcription activities
  JOURNAL   J Biol Chem 275 (30), 22815-22823 (2000)
   PUBMED   10801852
REFERENCE   6  (bases 1 to 1334)
  AUTHORS   Wu,L., Chen,P., Hwang,J.J., Barsky,L.W., Weinberg,K.I., Jong,A. and
            Starnes,V.A.
  TITLE     RNA antisense abrogation of MAT1 induces G1 phase arrest and
            triggers apoptosis in aortic smooth muscle cells
  JOURNAL   J Biol Chem 274 (9), 5564-5572 (1999)
   PUBMED   10026172
REFERENCE   7  (bases 1 to 1334)
  AUTHORS   Kershnar,E., Wu,S.Y. and Chiang,C.M.
  TITLE     Immunoaffinity purification and functional characterization of
            human transcription factor IIH and RNA polymerase II from clonal
            cell lines that conditionally express epitope-tagged subunits of
            the multiprotein complexes
  JOURNAL   J Biol Chem 273 (51), 34444-34453 (1998)
   PUBMED   9852112
REFERENCE   8  (bases 1 to 1334)
  AUTHORS   Drapkin,R., Le Roy,G., Cho,H., Akoulitchev,S. and Reinberg,D.
  TITLE     Human cyclin-dependent kinase-activating kinase exists in three
            distinct complexes
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6488-6493 (1996)
   PUBMED   8692842
REFERENCE   9  (bases 1 to 1334)
  AUTHORS   Reardon,J.T., Ge,H., Gibbs,E., Sancar,A., Hurwitz,J. and Pan,Z.Q.
  TITLE     Isolation and characterization of two human transcription factor
            IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6482-6487 (1996)
   PUBMED   8692841
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1996 Sep 17;93(19):10538]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078712.1.
            
            On Aug 8, 2004 this sequence version replaced NM_153472.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078712.1, AY135567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1334
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1334
                     /gene="Mnat1"
                     /note="MNAT1 component of CDK activating kinase"
                     /db_xref="GeneID:266713"
                     /db_xref="RGD:628874"
     exon            1..143
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    43..45
                     /gene="Mnat1"
                     /note="upstream in-frame stop codon"
     CDS             55..984
                     /gene="Mnat1"
                     /note="menage a trois 1; menage a trois homolog 1, cyclin
                     H assembly factor; MNAT CDK-activating kinase assembly
                     factor 1; MNAT1, CDK activating kinase assembly factor"
                     /codon_start=1
                     /product="CDK-activating kinase assembly factor MAT1"
                     /protein_id="NP_703202.1"
                     /db_xref="GeneID:266713"
                     /db_xref="RGD:628874"
                     /translation="

MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLENTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQESEQRRLFIQKEEELQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKSMKPVTFSTGIKMGQQISLAPIQKLEEALYEYQPLQIETCGPQVPEQELLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPR"

     misc_feature    55..978
                     /gene="Mnat1"
                     /note="CDK-activating kinase assembly factor MAT1; Region:
                     cdk7; TIGR00570"
                     /db_xref="CDD:129661"
     exon            144..296
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..370
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..474
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..615
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..741
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..863
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1302
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtggcagtggctgaagctggcgttggggggaaaatccaaagctgaggagacgccatggacgaccagggctgccccaggtgtaagaccaccaaataccggaacccttctttgaagctgatggtgaacgtgtgcggacacacactgtgtgagagttgtgtggacttactgtttgtaagaggagctggaaactgtccggagtgtggcactccactgagaaagagcaactttagggtacagctctttgaagatcccactgttgacaaggaggttgaaattcggaaaaaagtactaaagatatacaataaaagggaagaagattttcctagtttaagagagtataatgattttctggaagaagtggaggaaatcgttttcaatttgaccaacaacgtggatttggagaacactaaaaagaaaatggaaatatatcaaaaagaaaacaaagatgtcattcagaaaaataaattaaagctgactcgggagcaggaggaattggaggaagcattggaggtagaacgccaagaaagtgaacaacgacgactgtttattcaaaaggaagaagagctgcagcagattctgaaaaggaagaacaagcaggcctttttagatgagctggagagctccgacctccctgtcgctctgctcttggctcagcataaagacagatctacccagctggaaatgcagcttgagaagcccaaatccatgaagccggtgacattttccacaggaattaaaatgggtcaacagatttcgttagcaccaatccaaaagcttgaggaagctctctatgaataccagcccctgcagatagagacctgtggaccccaagttcctgaacaagagctgctaggaagacttgggtatttgaaccacgtccgagctgcatctccacaggatctagctggcggctatacttcttctcttgcttgtcacagagcgctacaggatgcattcagtgggcttttctggcagcccagatagcctgtattttctcatttataaaatctggatcttggaaccaaaccaaggggtttggaagtaaagaaatttgtaaagtcccagcccacgcagctgcacagcacaccaccgctggctgctgtgttcaggtgtttatggcagtctggaccaagctgagaaatgtgttgcatatagattcatggaagagatttattttttacttctattcttcagacagggatcgaagcattgaacctcatataacaagaaagaaataaatgatttgcctatgtatggtgttgacatacattttttaaaacaataaagcttgactttatgataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

//