LOCUS       NM_023985               1972 bp    mRNA    linear   ROD 06-OCT-2023
DEFINITION  Rattus norvegicus tribbles pseudokinase 1 (Trib1), mRNA.
ACCESSION   NM_023985 XM_001065461 XM_343250
VERSION     NM_023985.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Ram R, Wakil SM, Muiya NP, Andres E, Mazhar N, Hagos S, Alshahid M,
            Meyer BF, Morahan G and Dzimiri N.
  TITLE     A common variant association study in ethnic Saudi Arabs reveals
            novel susceptibility loci for hypertriglyceridemia
  JOURNAL   Clin Genet 91 (3), 371-378 (2017)
   PUBMED   27599772
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K,
            Yoshioka Y, Morii E, Takakura N, Takeuchi O and Akira S.
  TITLE     Critical role of Trib1 in differentiation of tissue-resident
            M2-like macrophages
  JOURNAL   Nature 495 (7442), 524-528 (2013)
   PUBMED   23515163
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Dedhia PH, Keeshan K, Uljon S, Xu L, Vega ME, Shestova O,
            Zaks-Zilberman M, Romany C, Blacklow SC and Pear WS.
  TITLE     Differential ability of Tribbles family members to promote
            degradation of C/EBPalpha and induce acute myelogenous leukemia
  JOURNAL   Blood 116 (8), 1321-1328 (2010)
   PUBMED   20410507
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H,
            Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T and
            Akira S.
  TITLE     Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1
            deficiency
  JOURNAL   J Exp Med 204 (9), 2233-2239 (2007)
   PUBMED   17724128
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   Sung HY, Guan H, Czibula A, King AR, Eder K, Heath E, Suvarna SK,
            Dower SK, Wilson AG, Francis SE, Crossman DC and Kiss-Toth E.
  TITLE     Human tribbles-1 controls proliferation and chemotaxis of smooth
            muscle cells via MAPK signaling pathways
  JOURNAL   J Biol Chem 282 (25), 18379-18387 (2007)
   PUBMED   17452330
REFERENCE   6  (bases 1 to 1972)
  AUTHORS   Kiss-Toth E, Bagstaff SM, Sung HY, Jozsa V, Dempsey C, Caunt JC,
            Oxley KM, Wyllie DH, Polgar T, Harte M, O'neill LA, Qwarnstrom EE
            and Dower SK.
  TITLE     Human tribbles, a protein family controlling mitogen-activated
            protein kinase cascades
  JOURNAL   J Biol Chem 279 (41), 42703-42708 (2004)
   PUBMED   15299019
REFERENCE   7  (bases 1 to 1972)
  AUTHORS   Volpe CM, Koo J, Miloro SM, Driscoll DL, Nava HR and Douglass HO
            Jr.
  TITLE     The effect of extended lymphadenectomy on survival in patients with
            gastric adenocarcinoma
  JOURNAL   J Am Coll Surg 181 (1), 56-64 (1995)
   PUBMED   7599772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI601976.1, AW530250.1, BE096693.1, AF205438.1 and AA964141.1.
            
            On or before Jan 20, 2007 this sequence version replaced
            XM_343250.3, XM_001065461.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF205438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AI601976.1         1-317               c
            318-354             AW530250.1         7-43                c
            355-625             BE096693.1         1-271
            626-639             AF205438.1         2-15
            640-819             BE096693.1         286-465
            820-1713            AF205438.1         196-1089
            1714-1972           AA964141.1         10-268
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1972
                     /gene="Trib1"
                     /gene_synonym="Gig2"
                     /note="tribbles pseudokinase 1"
                     /db_xref="GeneID:78969"
                     /db_xref="RGD:621596"
     exon            1..964
                     /gene="Trib1"
                     /gene_synonym="Gig2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    227..229
                     /gene="Trib1"
                     /gene_synonym="Gig2"
                     /note="upstream in-frame stop codon"
     CDS             605..1723
                     /gene="Trib1"
                     /gene_synonym="Gig2"
                     /note="G-protein-coupled receptor induced protein GIG2"
                     /codon_start=1
                     /product="tribbles homolog 1"
                     /protein_id="NP_076475.1"
                     /db_xref="GeneID:78969"
                     /db_xref="RGD:621596"
                     /translation="

MRVGPVRFALSGASQPRGPALLFPAARGTPAKRLLDTDDAAAVAAKCPRLSECSNPPDYLSPPGSPCSPQPPPSAQGTGGSCVSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYTQLPSHRNITGIVEVILGESKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHMIKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHVSPKARCLIRSLLRREPSERLTAPEILLHPWFEYVLEPGYVDSEVGTSDQIVPEYQDDNDVSSFFC"

     misc_feature    893..1618
                     /gene="Trib1"
                     /gene_synonym="Gig2"
                     /note="Pseudokinase domain of Tribbles Homolog 1; Region:
                     PK_TRB1; cd14023"
                     /db_xref="CDD:270925"
     exon            965..1257
                     /gene="Trib1"
                     /gene_synonym="Gig2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1972
                     /gene="Trib1"
                     /gene_synonym="Gig2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

acacagcccgggctgtgagtgtgtgtgtgtgtatacagcgtgagtcaccgggaggcggaggaggtggaggaaaaggagaaggagtgcactggccgggatcagtgcggcacacactcatattcagtcactctctctaagcgcgtctcgctcgctcacacgcctggagcccaggagcgcgcaggatcccgagcggcgcggaaaagttgcaccggcttttactcaagactaattgctttgggaagtgcgtttgctcggtgaagccaacgagcctgcggaatctgtcctccaggctcagcacccgggaactcgggcggcctccacgtcccgggctatccacggtctcggcaacaatagcggccgccaccgccagcgaggcgtccagacctggtgcctgccggggtctggggaccttagccggcctcccacccttggacgcgtggccagtgtggttctcgtgtacaacatcagcgtcctggaactgctctcgttttgctccttttggggaccgatccaagctctatctgcagactccatcccgcggactggaagtcgtagcgcggatccagggatttacaaagccggggccgctccggccagggccgcgatgcgggtcggtcccgtgcgttttgccctgagcggcgcctcgcagccccgcggaccggctctactgttcccggctgcccggggcaccccggccaaacgcctgctggacacggacgacgcggcggccgtggcggccaagtgtccgcgcctctctgagtgctcgaatccccctgactacctcagtccccccggctcgccctgcagtcctcagcctccaccctcggcgcaggggaccggcggcagctgtgtgagcgcacccgggcccagccgaatcgccgactacctgctgctacccctagctgagcgcgagcatgtgtcccgggcactgtgcatccacaccggccgcgagctgcgctgcaaggtgtttcccattaaacactaccaagacaaaatcaggccttacacccagctgccgtcccatagaaacattactggcatcgtggaagtgatcctcggggagagcaaggcctacgttttctttgagaaggactttggagacatgcactcctatgtacgaagccggaaaaggcttcgggaagaggaggccgctcggctcttcaagcaaattgtttccgccgttgcccactgccaccagtcagccattgtgctgggggacctgaagcttaggaaattcgtcttctccacagaggagaggacccagcttagactggaaagcctagaagatacgcacatgataaagggtgaagatgacgcattgtcagataaacatggctgcccggcctatgtgagccctgagatcctcaacactactgggacctactccggaaaggcagcggatgtttggagccttggggtgatgctctacacccttttggtcggacgatacccctttcatgactcagacccgagcgcccttttctccaaaatccgtcggggacagttttgcattcccgagcatgtttcccccaaagccaggtgcctcatccgcagcctcctgagacgagaaccttctgagagactcacagctcctgagatcttactccatccctggtttgaatacgtcttggaaccggggtatgttgactcagaagtaggaacttctgaccagattgttcccgagtaccaggacgacaatgacgttagttcctttttctgctaatcccccccccccaaaaaaaaacctcagaaacctcataattctcacacatggcatttctaatgatgggcaggccctcttacacggtgccagccagctatggggacggagcaccattgtccctgtggggctcagtgtggtgccacctctcgggccgagtgacttgatttgaccagcatgcactcagattagctgcttgacaaaggtgtccccttttcgatgaccatcgtgactgtcccggtgtcggaggca

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