LOCUS       NM_001159566            4279 bp    mRNA    linear   MAM 24-JAN-2024
DEFINITION  Bos taurus transforming growth factor beta receptor 2 (TGFBR2),
            mRNA.
ACCESSION   NM_001159566 XM_615445
VERSION     NM_001159566.2
KEYWORDS    RefSeq.
SOURCE      Bos taurus (domestic cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (bases 1 to 4279)
  AUTHORS   Hirayama H, Koyama K, Sawai K, Fujii T, Naito A, Fukuda S and
            Kageyama S.
  TITLE     Localization of TGF-beta and TGF-beta receptor in bovine term
            placentome and expression differences between spontaneous and
            induced parturition
  JOURNAL   Placenta 36 (11), 1239-1245 (2015)
   PUBMED   26382756
  REMARK    GeneRIF: found in binucleate cells of placenta
REFERENCE   2  (bases 1 to 4279)
  AUTHORS   Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D,
            Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G,
            Roberts M, Subramanian P, Yorke JA and Salzberg SL.
  TITLE     A whole-genome assembly of the domestic cow, Bos taurus
  JOURNAL   Genome Biol. 10 (4), R42 (2009)
   PUBMED   19393038
REFERENCE   3  (bases 1 to 4279)
  AUTHORS   Chen CL, Huang SS and Huang JS.
  TITLE     Cholesterol modulates cellular TGF-beta responsiveness by altering
            TGF-beta binding to TGF-beta receptors
  JOURNAL   J. Cell. Physiol. 215 (1), 223-233 (2008)
   PUBMED   17972267
  REMARK    GeneRIF: These results indicate that high plasma cholesterol levels
            may contribute to the pathogenesis of certain diseases (e.g.,
            atherosclerosis) by suppressing TGF-beta responsiveness.
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from NKLS02000022.1.
            
            On Dec 20, 2018 this sequence version replaced NM_001159566.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6764281.28251.1,
                                           SRR5571254.2851.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA6648753, SAMEA6648754
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               NKLS02000022.1     5091591-5091914
            325-493             NKLS02000022.1     5129235-5129403
            494-684             NKLS02000022.1     5133699-5133889
            685-1484            NKLS02000022.1     5157821-5158620
            1485-1626           NKLS02000022.1     5160466-5160607
            1627-1754           NKLS02000022.1     5178319-5178446
            1755-4279           NKLS02000022.1     5181230-5183754
FEATURES             Location/Qualifiers
     source          1..4279
                     /organism="Bos taurus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9913"
                     /chromosome="22"
                     /map="22"
                     /breed="Hereford"
     gene            1..4279
                     /gene="TGFBR2"
                     /note="transforming growth factor beta receptor 2"
                     /db_xref="BGD:BT12096"
                     /db_xref="GeneID:535376"
                     /db_xref="VGNC:VGNC:35805"
     exon            1..324
                     /gene="TGFBR2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    210..212
                     /gene="TGFBR2"
                     /note="upstream in-frame stop codon"
     CDS             231..1934
                     /gene="TGFBR2"
                     /EC_number="2.7.11.30"
                     /note="transforming growth factor, beta receptor II
                     (70/80kDa)"
                     /codon_start=1
                     /product="TGF-beta receptor type-2 precursor"
                     /protein_id="NP_001153038.1"
                     /db_xref="BGD:BT12096"
                     /db_xref="GeneID:535376"
                     /db_xref="VGNC:VGNC:35805"
                     /translation="

MGRGLLGGLWPLHVVLWTRIASTIPPHVPKSVNSDMMVTDHNGAIKLSQLCKFCDVRSSTCDNQKSCWSNCSITAICEKPEEVCVAVWRKNDENITLETVCHDPKIAYHGFVLDDAASSKCIMKERKGSGETFFMCSCSSEECNDHIIFSEEYTSSNPDLLLVIFQVTGVSLLPPLGIAIAVIITFYCYRIHRQQKLSPAWDSGKPRKLMEFSEHLAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRRLGGSLARGIAHLHSDHTLCGRPKMPIVHRDLKSSNILVKGDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSSWLNHQGIQTVCETLAECWDHDPEARLTAQCVAERFSELEHLDRLSGRSSSEEKIPEDGSLNTTK"

     sig_peptide     231..299
                     /gene="TGFBR2"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    375..686
                     /gene="TGFBR2"
                     /note="Transforming growth factor beta receptor 2
                     ectodomain; Region: ecTbetaR2; pfam08917"
                     /db_xref="CDD:462632"
     misc_feature    972..1856
                     /gene="TGFBR2"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Transforming Growth Factor beta Type II Receptor; Region:
                     STKc_TGFbR2_like; cd14055"
                     /db_xref="CDD:270957"
     misc_feature    order(978..998,1002..1004,1053..1055,1059..1061,
                     1143..1145,1203..1214,1224..1226,1230..1232,1365..1367,
                     1371..1373,1377..1382,1386..1388,1419..1421,1428..1430,
                     1488..1499)
                     /gene="TGFBR2"
                     /note="active site"
                     /db_xref="CDD:270957"
     misc_feature    order(978..998,1002..1004,1053..1055,1059..1061,
                     1203..1208,1212..1214,1224..1226,1377..1382,1386..1388,
                     1419..1421)
                     /gene="TGFBR2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270957"
     misc_feature    order(990..992,1224..1226,1230..1232,1365..1367,
                     1371..1373,1377..1379,1428..1430,1488..1499)
                     /gene="TGFBR2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270957"
     misc_feature    1416..1499
                     /gene="TGFBR2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270957"
     exon            325..493
                     /gene="TGFBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..684
                     /gene="TGFBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1484
                     /gene="TGFBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1626
                     /gene="TGFBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1754
                     /gene="TGFBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..4279
                     /gene="TGFBR2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcacgccgggcccgacgacactccgcgcgcgcacccgccggccgggccggcctccagctccgctcccctcggccaccggggccccccgcgcctcgcccgccgccaccctccccgcggcccgccgcgccacatctggctgcaccgctgctgggcgcccggcgcgggtccggagggcgcggaggcgcggcgtacgcgctcgggccggtctatgaggagcggcgggggctgccatgggccgggggctgctcgggggcctgtggccgctgcacgtcgtcctgtggacgcgcatcgccagcacgatcccgccgcacgttcccaagtcggttaacagcgatatgatggtcactgaccacaacggcgccatcaagctgtcgcagctgtgtaagttctgcgacgtgcggtcgtccacctgtgacaaccagaagtcctgctggagcaactgcagcatcacggccatctgcgagaagccggaggaggtctgcgtggctgtctggaggaagaatgatgagaacatcacgctggagacagtctgccatgaccccaagattgcctaccatggatttgtcctggacgatgctgcttcttcaaagtgtatcatgaaggaaagaaaggggtccggagagactttcttcatgtgctcctgcagctccgaagaatgcaatgaccacattatcttctccgaagagtacaccagcagtaaccccgacttgctgctggttatcttccaagtgacaggcgtcagcctcctgccaccgctgggcatcgccatcgcagtcatcatcactttctactgctaccgcatccaccggcagcagaagctgagcccagcctgggactcgggcaagccgcgcaagctgatggagttcagtgagcacctggccatcatcctggaggacgaccgctccgacatcagctccacctgcgccaacaacatcaaccacaacacggagctgctgcccatcgagctggacaccctggtgggcaaggggcgcttcgccgaggtctacaaggccaagctgaagcagaacacgtctgagcagttcgagaccgtggccgtcaagatcttcccctacgaggagtatgcctcctggaagacggagaaggacatcttctcggacatcaacctcaagcacgagaacatcctgcagttcctgacggccgaggagcgcaagacggagctgggcaagcagtactggctcatcactgccttccacgccaagggcaacctgcaggagtacctgacgcgccacgtcatcagctgggaggacctgcgccggctgggcggctcgctggcccgcggcatcgcgcacctgcacagcgaccacaccctgtgcggccggcccaagatgcccatcgtgcacagggacctcaagagctccaacatcctggtcaagggcgacctcacctgctgcctctgcgacttcgggctctcactgcggctggaccccaccctgtcagtggatgacctggccaacagtgggcaggtgggaacggcgagatacatggctccagaggtcctcgagtccaggatgaatctggagaacgtggagtccttcaagcagacggatgtctactccatggccctggtgctctgggagatgacgtctcgctgcaacgcagtgggagaagtgaaggactatgagcctccgttcgggtctaaggtgcgggagcatccctgtgtggaaagcatgaaggacaacgtgctgagagatcgaggccgaccagagattcccagctcctggctcaaccaccagggcatccagacggtgtgcgagacgctggccgaatgctgggaccatgaccccgaggcccggctcacggcgcagtgcgtggccgagcgcttcagcgagctggagcacctggacaggctctccgggaggagcagctcggaggagaagatccccgaagatggctccctcaacactaccaaatagctcttcccgcggccggcccagcgcggccgccctgtggccaaagagcagggtcagcagaaagctgcccctgacgatgcttcctggaacccggggtgctccctcccccgagctgggagggggtggcaggaagcagcttctgcctttgacgttgtcataggataagctgtgttagcacttcctcaggaaatgagattgatcttacaatagccaataacatttgcactttattaatgcctgtatataaatatgaaatagctatgtttatatatatctatatatgtctatatatacacagccatacttgtggaaagagatgaggacagagaccacacgtgcccagacgtgggctggatgggcagcctcagcacttggcggcacgcgtgtgctgggctcggggcacacggggagggggtctctgcctttagagagaggctcgggtctaggagcctgctgtgccgcattgcacttgcttttgcaacgtagtaactccctgcactgggtcctgtcctggctgtggagccaagtggagccgcactgtctggggaccagaccccaaggtccccacgtcccatcatctctcctggactcggcactgagcgtcacacccacgtttgttttgtgaacctctgtcctcagctagctcagaaagtctcatcgcgtcaacgttttaagtcccatcttttacctccacaagctacagaaaaatcaggacatgttttccctacccgtgaaattgccacaccttgtactaatgagaaaatgttctttttaaaaaaatccccccctccacctatgttactgttccccatttcctaaaagggcacagatctcccttccaggctctttatgttcagtttttcatcacgctcggtttctgtcttccgcttgccatgcatcactggtgggtctcaggctccagggggacttgagcacgttttggccacgtggacagtattgaagcagcattgtgctgccacagtcaggactgtccaggcactcggaacgtgcatcttgcttggccagcacagtgtttaacaaaattgagccactttttaaatatctggagattttgcaaacaaattttggatccccgagtgagactagatagctgatggcttacagttctcgctgtgccacgtcattcacagatgatggtgtagacacacttagaaagctgctctcttcccctgtgaacattcgtgtttccccctgttctcaccctagtttgggaattaaaccttctttccccagccaaggttccctgcaagaaatgtgcattcacgcaatcattctctggctatagagtgtcgttttgattcccttcctggggttaaaattcgaagttggcctttttttttttttggagtgacagggactgcctctggatggtccctattaacccaaatctcttttgcttgtatattaaagagtgttcccctttgcattcaaagggggagacctttactccaagaagttgttgtcatggttaccagtctcttagtcatacccaccttcccaatgtttgcagaatttgaatgtgggatgcaggagtcccatctacagttaggaaatatgtgtccatgtgggtaagaacaaagaatgagctttaatcctccataagaaacttggtaatccacaaacaggtgttaatgctgcaaataacaagctcttttgtaaacatgatttgaagcttattttcagccaaataggtaggaatattggagagggactggcaatgatcagatcagctctgcttgggttttggaagccgcatctcattggggttttagcagacacgctgaagttgggattaagtggaatttttaggaacccttcttggttcaagtggactgagagagattaggcagtttggccacaatgccatggaagtgcccagaagtcccgtgcactttagggctggtgatgctgtcccaatagctgttgctcattgacctctagtggtgaatttctagaatactggtccattatgggaactgccaagattcaaaagagctttatcacttctgggtcatcatcagcataaactggaatgtagatgatactgtggcttgttttatgtgtgttttttccttattcaagaaaaagaccaaggaataacattctgtagttcctaaaaatactgacttttttcactacgtaaagggaaagttgtattcttttatggaacatttcagcaatactcatgtattaaaataggaatgtgaatgctgtatactctttttatatcaaatgtgtcaagcacttattttcattctatgcattgtttgtcttttatataaataaaatgtttattcgattgaataaagcaaaagtactcaggtcag

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