LOCUS       NM_001076378            1349 bp    mRNA    linear   MAM 24-JAN-2024
DEFINITION  Bos taurus aquaporin 7 (AQP7), mRNA.
ACCESSION   NM_001076378 XM_867324
VERSION     NM_001076378.2
KEYWORDS    RefSeq.
SOURCE      Bos taurus (domestic cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (bases 1 to 1349)
  AUTHORS   Fujii T, Hirayama H, Fukuda S, Kageyama S, Naito A, Yoshino H,
            Moriyasu S, Yamazaki T, Sakamoto K, Hayakawa H, Takahashi K,
            Takahashi Y and Sawai K.
  TITLE     Expression and localization of aquaporins 3 and 7 in bull
            spermatozoa and their relevance to sperm motility after
            cryopreservation
  JOURNAL   J. Reprod. Dev. 64 (4), 327-335 (2018)
   PUBMED   29798965
  REMARK    GeneRIF: Our findings suggest that AQP3 and AQP7 are possibly
            involved in the tolerance to freeze-thawing in bull spermatozoa,
            particularly in the sperm's tail.
REFERENCE   2  (bases 1 to 1349)
  AUTHORS   Prieto-Martinez N, Morato R, Muino R, Hidalgo CO, Rodriguez-Gil JE,
            Bonet S and Yeste M.
  TITLE     Aquaglyceroporins 3 and 7 in bull spermatozoa: identification,
            localisation and their relationship with sperm cryotolerance
  JOURNAL   Reprod. Fertil. Dev. 29 (6), 1249-1259 (2017)
   PUBMED   27221122
  REMARK    GeneRIF: Data suggest that AQP3 is localized to mid-piece of bull
            spermatozoa; AQP7 is localized to mid-piece and post-acrosomal
            region of bull spermatozoa. Neither relative abundance of AQP3 or
            AQP7 nor their localization patterns is altered by
            cryopreservation; individual differences between bull ejaculates
            appear to be common. Abundance of AQP7 is higher in ejaculates with
            good versus poor freezability in cryopreservation.
REFERENCE   3  (bases 1 to 1349)
  AUTHORS   Sauerwein H, Saremi B, Pappritz J, von Soosten D, Meyer U, Danicke
            S and Mielenz M.
  TITLE     Short communication: aquaporin-7 mRNA in adipose depots of
            primiparous and pluriparous dairy cows: long-term physiological and
            conjugated linoleic acid-induced changes
  JOURNAL   J. Dairy Sci. 96 (7), 4508-4513 (2013)
   PUBMED   23684044
  REMARK    GeneRIF: a modulatory effect of conjugated linoleic acids on
            aquaporin 7 messenger RNA abundance in dairy cows is not supported
            by our study
REFERENCE   4  (bases 1 to 1349)
  AUTHORS   Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D,
            Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G,
            Roberts M, Subramanian P, Yorke JA and Salzberg SL.
  TITLE     A whole-genome assembly of the domestic cow, Bos taurus
  JOURNAL   Genome Biol. 10 (4), R42 (2009)
   PUBMED   19393038
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC109728.1.
            
            On Aug 30, 2012 this sequence version replaced NM_001076378.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109728.1, DV923871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04019637 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1349              BC109728.1         2-1350
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Bos taurus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9913"
                     /chromosome="8"
                     /map="8"
                     /breed="mixed"
     gene            1..1349
                     /gene="AQP7"
                     /note="aquaporin 7"
                     /db_xref="BGD:BT21034"
                     /db_xref="GeneID:615498"
     exon            1..241
                     /gene="AQP7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    190..192
                     /gene="AQP7"
                     /note="upstream in-frame stop codon"
     exon            242..290
                     /gene="AQP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1257
                     /gene="AQP7"
                     /codon_start=1
                     /product="aquaporin-7"
                     /protein_id="NP_001069846.1"
                     /db_xref="BGD:BT21034"
                     /db_xref="GeneID:615498"
                     /translation="

MTQSDRKRRSTRVSKVVSTPTATKMQVIWQNENVREFLAEFISTYVMMVFGLGAVADMVLGGKMGSYLAVNLGFGFGVTIGVHMAGNISGAHMNAALTFTSCALGRMSWKKFPVYVLGQFLGSFVAAATIYGLFYNAIIDFSGGKLMTTGPTATANIFATYLPDHMTLWRGFLDEVVVTGMLQLCLLAIADKGNNPTLLGTQAIVTGILVVIIGISLGMNSGYAINPSRDLPPRFFTFLAGWGSQVFRTKDWWWVPVVAPPLGAYCGAIIYLFFIGSNKRQEPQVLENPLAFEDHKISVLPKTTSHQHGVASLTPVSVYPEDRPSALYHP"

     misc_feature    322..1092
                     /gene="AQP7"
                     /note="Major intrinsic protein (MIP) superfamily. Members
                     of the MIP superfamily function as membrane channels that
                     selectively transport water, small neutral molecules, and
                     ions out of and between cells. The channel proteins share
                     a common fold: the N-terminal...; Region: MIP; cl00200"
                     /db_xref="CDD:444743"
     misc_feature    order(484..486,538..546,928..933,940..942,949..951)
                     /gene="AQP7"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(544..552,940..948)
                     /gene="AQP7"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     exon            291..408
                     /gene="AQP7"
                     /inference="alignment:Splign:2.1.0"
     exon            409..532
                     /gene="AQP7"
                     /inference="alignment:Splign:2.1.0"
     exon            533..670
                     /gene="AQP7"
                     /inference="alignment:Splign:2.1.0"
     exon            671..789
                     /gene="AQP7"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1007
                     /gene="AQP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1334
                     /gene="AQP7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gagtgacaagggccaaacccctgctccactgacctcttccctggaggagcagagcagagcagcactcgggtcgccctgaggagggctgagaggcgggctctggctggggacatagggaccacagagccctggcaggggctgcagccagagcctgagacggtcatggaggaagctgtccaggggctgctgtgactgagaggccccaaggcaggcaactgggagcataaggcctttcagcagacatctaaaaatctcaaagacaatatgactcagtcagacaggaagaggcggtccacccgcgtgtccaaggtggtctcgacacctacagcaacaaagatgcaagtcatatggcagaacgagaatgttcgagagttcctggcggagttcatcagcacgtatgtcatgatggtgttcggtctcggcgccgtggccgacatggttctaggaggtaaaatggggagctacctcgctgtcaatttgggttttggcttcggagtcaccataggtgtgcacatggcggggaacatctctggggcccatatgaatgcggccttgaccttcaccagctgtgcgctaggccgcatgtcctggaagaagtttcccgtgtacgttctgggtcagttcctgggctccttcgtggcggcggccaccatctacggcctcttctacaacgctattatcgacttctcggggggaaagctgatgacgaccggccccacagccactgctaacatttttgccacctaccttcctgaccacatgacactgtggaggggcttcctggatgaggtggtggtgactgggatgcttcagctgtgtctcttagccatcgcagacaaggggaacaacccaacgctgttggggacgcaggccattgtgactggcatccttgttgtcatcatcggaatatccctgggcatgaactcaggatatgccatcaacccatcccgggacctgcctccccgcttcttcaccttcctcgctggctggggctcacaagtcttcagaaccaaggactggtggtgggtgccggtggtggcaccacccctgggtgcctactgtggtgccatcatctacttgttcttcattggctccaacaaacgacaggagccccaggtcctggagaatcccttggcgtttgaagaccacaaaatatctgtgttgcccaagaccacgtctcaccagcatggggtcgcttccctcacccctgtttccgtgtaccccgaagatagaccctcagccttgtaccacccttaagtgactccatctgcctagagcccctctaagactatttgtgaccctacatccaccccaataaagaaagccttgtcccaaaaaaaaaaaaaaaa

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