LOCUS       NM_001009470            1520 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cyclin B2 (Ccnb2), mRNA.
ACCESSION   NM_001009470 XM_343419
VERSION     NM_001009470.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   3  (bases 1 to 1520)
  AUTHORS   Nishihara,K., Masuda,S., Nakagawa,S., Yonezawa,A., Ichimura,T.,
            Bonventre,J.V. and Inui,K.
  TITLE     Impact of Cyclin B2 and Cell division cycle 2 on tubular
            hyperplasia in progressive chronic renal failure rats
  JOURNAL   Am J Physiol Renal Physiol 298 (4), F923-F934 (2010)
   PUBMED   20071461
  REMARK    GeneRIF: These results advance the knowledge of cell cycle
            regulators effects in tubular restoration and/or degeneration, and
            the cyclin b2 and CDC2 molecules are suggested to be a marker for
            the proliferation of proximal tubular cells in kidney failure.
REFERENCE   4  (bases 1 to 1520)
  AUTHORS   Kuroda,T., Naito,K., Sugiura,K., Yamashita,M., Takakura,I. and
            Tojo,H.
  TITLE     Analysis of the roles of cyclin B1 and cyclin B2 in porcine oocyte
            maturation by inhibiting synthesis with antisense RNA injection
  JOURNAL   Biol Reprod 70 (1), 154-159 (2004)
   PUBMED   12954723
REFERENCE   5  (bases 1 to 1520)
  AUTHORS   Brandeis,M., Rosewell,I., Carrington,M., Crompton,T., Jacobs,M.A.,
            Kirk,J., Gannon,J. and Hunt,T.
  TITLE     Cyclin B2-null mice develop normally and are fertile whereas cyclin
            B1-null mice die in utero
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4344-4349 (1998)
   PUBMED   9539739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088212.1.
            
            On Jan 7, 2005 this sequence version replaced XM_343419.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088212.1, BC097952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1520
                     /gene="Ccnb2"
                     /note="cyclin B2"
                     /db_xref="GeneID:363088"
                     /db_xref="RGD:1308176"
     exon            1..92
                     /gene="Ccnb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1265
                     /gene="Ccnb2"
                     /codon_start=1
                     /product="G2/mitotic-specific cyclin-B2"
                     /protein_id="NP_001009470.1"
                     /db_xref="GeneID:363088"
                     /db_xref="RGD:1308176"
                     /translation="

MALLRRPTVSSDLKNIDTGVNPKAKSHVTVRRAVLEEIGNKVRARPAQVAKKPQNTKVPVQPTKAINASKQPKPTASVKPVQMETLAPKDPLPAPEDVSMKEESLCQAFSDALLCKIEDIDNEDGENPQLCSDYVKDIYQYLRQLEALQSINPHFLDGRDINGRMRAILVDWLVQVHSKFRLLQETLYMCIAIMDRFLQAQPVCRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQHTLAKYLMELTLVDYDMVHYHPSQVAAAASCLSQKVLGQGKWNLKQQYYTGYMESEILEVMQHMAKNVVKVNENLTKFIAVKNKYASSRLLKISTIPQLNSRTIKDLASPLMGRP"

     misc_feature    447..845
                     /gene="Ccnb2"
                     /note="Cyclin box fold superfamily; Region: CYCLIN_SF;
                     cl40454"
                     /db_xref="CDD:477360"
     misc_feature    858..1214
                     /gene="Ccnb2"
                     /note="second cyclin box found in G2/mitotic-specific
                     cyclin-B2 (CCNB2) and similar proteins; Region:
                     CYCLIN_CCNB2_rpt2; cd20570"
                     /db_xref="CDD:410273"
     exon            93..221
                     /gene="Ccnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..335
                     /gene="Ccnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..506
                     /gene="Ccnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..665
                     /gene="Ccnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..902
                     /gene="Ccnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1043
                     /gene="Ccnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1154
                     /gene="Ccnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1488
                     /gene="Ccnb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctgagactcccaacggtgtcgcggatcggagtggcagtgcctcgtccgcacttgccagagcggccctcatggcgctgctccgacgcccgacggtgtccagtgatttgaagaatattgacacaggagttaatcctaaagctaagagccatgtgactgtccggcgagctgttttagaagaaattggaaataaagttagagccagaccggctcaagtggctaagaaacctcagaataccaaagtaccagtccagcccaccaaagcaataaatgccagcaaacagccgaaacctacagcttctgtgaaaccagtgcagatggagacactggccccgaaggatcctctgcctgcccctgaggatgtctccatgaaggaagagagcctctgccaagctttctctgatgctttgctctgcaagattgaggacatagataatgaggacggggagaaccctcagctctgcagtgactacgtgaaggacatctaccagtacctcaggcagcttgaggctttgcagtccatcaatccacatttcttagatggaagagacataaacggacgcatgcgtgccatcctggtggactggctggtccaagtccattccaagtttaggcttctgcaggagactctgtacatgtgcattgctatcatggaccggttccttcaggctcagccagtctgccggaagaagctgcaactggttgggatcacagctctgctcttggcttccaaatatgaggagatgttttctccaaatatcgaagactttgtttatatcacagataatgcttacaccagttcccaaatccgagaaatggagactctgattttgaaagagttgaaattcgagttgggccggcctttgccactccacttcctaaggcgagcctcaaaagccggggaggtggatgttgaacagcacacgttagccaagtacctgatggagctgaccctcgtcgactacgacatggtgcattaccacccttctcaggtcgcagctgctgcttcctgcctctctcagaaggtgctgggccaaggaaaatggaatttaaagcagcagtattacacaggctacatggagagtgaaatactggaagtcatgcagcacatggccaagaacgtcgtgaaagtcaatgaaaacctcaccaagttcatcgctgtcaagaacaaatatgccagcagcaggctcctgaagatcagcacgatccctcagctgaactccagaaccatcaaagacctggcctcccctctgatgggcagaccctaggcagccgggcttccttccatcgtgtgcttctcagatttgtatatattctagtttacatcacaaaacctaattttctaattgtgtattgatgaaaaataaagctattgattttcttaaggtacccgtgtatatctgtatgctctatactgaagaaatgtagaatggcctaccataaccgtgctctgtactgaagaaaaataaagccactgatttacttaaggtaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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