LOCUS       NM_131637               1968 bp    mRNA    linear   VRT 04-JAN-2026
DEFINITION  Danio rerio claudin 7b (cldn7b), mRNA.
ACCESSION   NM_131637
VERSION     NM_131637.3
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Zhang,F., Tian,J., Li,J., Zhang,T. and Wang,X.
  TITLE     ILA mitigates HFD-induced metabolic dysfunction via lipid-immune
            crosstalk and gut microbiota modulation in zebrafish
  JOURNAL   Fish Shellfish Immunol 167, 110683 (2025)
   PUBMED   40865746
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Jedrychowska,J., Vardanyan,V., Wieczor,M., Marciniak,A., Czub,J.,
            Amini,R., Jain,R., Shen,H., Choi,H., Kuznicki,J. and Korzh,V.
  TITLE     Mutant analysis of Kcng4b reveals how the different functional
            states of the voltage-gated potassium channel regulate ear
            development
  JOURNAL   Dev Biol 513, 50-62 (2024)
   PUBMED   38492873
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Mi,J., Liu,K.C. and Andersson,O.
  TITLE     Decoding pancreatic endocrine cell differentiation and beta cell
            regeneration in zebrafish
  JOURNAL   Sci Adv 9 (33), eadf5142 (2023)
   PUBMED   37595046
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Lu,F., Leach,L.L. and Gross,J.M.
  TITLE     A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes
            in the zebrafish retinal pigment epithelium
  JOURNAL   Sci Rep 13 (1), 3142 (2023)
   PUBMED   36823429
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Zhang,F.L., Yang,Y.L., Zhang,Z., Yao,Y.Y., Xia,R., Gao,C.C.,
            Du,D.D., Hu,J., Ran,C., Liu,Z. and Zhou,Z.G.
  TITLE     Surface-Displayed Amuc_1100 From Akkermansia muciniphila on
            Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal
            Health in High-Fat-Fed Zebrafish
  JOURNAL   Front Nutr 8, 726108 (2021)
   PUBMED   34722607
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   Clelland,E.S. and Kelly,S.P.
  TITLE     Tight junction proteins in zebrafish ovarian follicles: stage
            specific mRNA abundance and response to 17beta-estradiol, human
            chorionic gonadotropin, and maturation inducing hormone
  JOURNAL   Gen Comp Endocrinol 168 (3), 388-400 (2010)
   PUBMED   20553723
REFERENCE   7  (bases 1 to 1968)
  AUTHORS   Davey,C., Tallafuss,A. and Washbourne,P.
  TITLE     Differential expression of neuroligin genes in the nervous system
            of zebrafish
  JOURNAL   Dev Dyn 239 (2), 703-714 (2010)
   PUBMED   20063411
REFERENCE   8  (bases 1 to 1968)
  AUTHORS   Reischauer,S., Levesque,M.P., Nusslein-Volhard,C. and Sonawane,M.
  TITLE     Lgl2 executes its function as a tumor suppressor by regulating ErbB
            signaling in the zebrafish epidermis
  JOURNAL   PLoS Genet 5 (11), e1000720 (2009)
   PUBMED   19911055
REFERENCE   9  (bases 1 to 1968)
  AUTHORS   Wang,D., Jao,L.E., Zheng,N., Dolan,K., Ivey,J., Zonies,S., Wu,X.,
            Wu,K., Yang,H., Meng,Q., Zhu,Z., Zhang,B., Lin,S. and Burgess,S.M.
  TITLE     Efficient genome-wide mutagenesis of zebrafish genes by retroviral
            insertions
  JOURNAL   Proc Natl Acad Sci U S A 104 (30), 12428-12433 (2007)
   PUBMED   17640903
REFERENCE   10 (bases 1 to 1968)
  AUTHORS   Loh,Y.H., Christoffels,A., Brenner,S., Hunziker,W. and Venkatesh,B.
  TITLE     Extensive expansion of the claudin gene family in the teleost fish,
            Fugu rubripes
  JOURNAL   Genome Res 14 (7), 1248-1257 (2004)
   PUBMED   15197168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000010.1.
            
            On Jun 25, 2025 this sequence version replaced NM_131637.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ011788.1, BC066408.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505372,
                                           SAMEA3505373 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               JBMGRA010000010.1  27046352-27046750   c
            400-564             JBMGRA010000010.1  27044240-27044404   c
            565-649             JBMGRA010000010.1  27043892-27043976   c
            650-1968            JBMGRA010000010.1  27041208-27042526   c
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..1968
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="claudin 7b"
                     /db_xref="GeneID:60635"
                     /db_xref="ZFIN:ZDB-GENE-001103-5"
     exon            1..399
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    159..161
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="upstream in-frame stop codon"
     CDS             177..824
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="claudin-like protein ZF4A22; claudin-7"
                     /codon_start=1
                     /product="claudin-7-B"
                     /protein_id="NP_571712.1"
                     /db_xref="GeneID:60635"
                     /db_xref="ZFIN:ZDB-GENE-001103-5"
                     /translation="

MAHKGLQLLGFTLSLLGLIGLIIGTIMPQWKMSAYVGDNIITAIAMYQGLWMSCAYQSTGQQQCKVYDSVLQLDSALQATRALMVVAILLTVAGLGVASMGMKCTNCGGDDKVKKSRIAMTGGIILSVGALCSIVACGWFTSQIIRDFYNPFTPVNTKYEFGAAIFIAWAGAFLDIMGGGMLASSCSKGQSSPNYPKSSRPVKSSRPPSSSKEYV"

     misc_feature    186..722
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; pfam00822"
                     /db_xref="CDD:395662"
     misc_feature    198..260
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    420..482
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    528..590
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    663..725
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    732..821
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            400..564
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
     exon            565..649
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
     exon            650..1968
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tgcggcttcggtgaacaggtgtttgagtcagggcttctccgatttttatttacattttaaacttattttattattttgaccaattcataatcggaaggctgctgaaagcgagcgatatttggacactaataagttatttgctaagcaggtttagtttttaaactcattctgagaagatggcacataaaggactgcaactcctagggtttactctatcgttgctagggttgattgggctcattattggcacaatcatgccccagtggaagatgtctgcttacgttggagataatataatcacagctattgcgatgtaccagggcctttggatgtcgtgcgcttaccagagcaccggccaacagcaatgcaaggtgtatgactccgtcctacaactcgacagtgctctccaggcaactcgtgcccttatggttgtagcaattcttcttacagtagctggactgggtgtggccagcatgggcatgaagtgtactaactgtggtggtgatgacaaggtcaaaaagtcccgcattgccatgacaggcggtataatcctctctgttggagccctctgtagcattgttgcctgtggctggtttacaagtcaaattatcagggatttctacaaccccttcacacctgtcaatacaaagtatgaatttggtgcagctattttcatcgcctgggctggtgcatttctcgatataatgggtggaggcatgttggcctcttcttgctcaaagggtcagtcatctcctaattaccctaagtcctccagacccgtcaagtcctccagaccacccagcagcagcaaggaatatgtttgagccatttgttcacgagctggaaaggacatgatcaatcccagagcatgggtagaagtttgccctgtcagctgatatgagatctgtttaatttggtttgtatgtttgactatagatagaaaaaacagctcagaaaggtatttttggccaacttttacttgtgttctgatacagcagcccaccaaaaatggtcacttctttcttttggttagctccttgttccaccttccccaccccgattataaaatgtgagtttgcaaaggggcttcttccccagagtcttcctcatttcagattactgtcacctttagtgaacatgaaagagggagacctgctcagggaaaaatcattactcatactgctctgttacaccacatctctgcttccagctgttaaacccttgcttgcatcattttaggaactgcgccagacactgaggtgcttatgaacaattaatacatgcattacatttttaaagctaagagtaacatgcaaataacctggttcactttgcagtcttttccctgtctggtccccatgccagcagaaacttttttcatacttcattttatacaaattagcaccctttaggtgaagtttcactcgtaagttcaatgaatcattcttttcagtgtatgctgatgaagctggattaaaactttagatggaaaaatgaagattaatttggtttggatgaggcttaacatgaagcactaaaatcaaattgctctttcttatgcaacatgaaccttttgatttgctgttgtcctttgttttgagtgtacaccttggtttttgtgcccatttaggaaggtaacatgttttttgtttttatacactccattaattggtcacaaaaaagctgtgaatattggcttagttgaatcactgctggttccaactatttttatgttaatgtaaaacttttttttatccataatatgaacatttaaaactggactatacttttttttttttttgctttggtctgtgcttgaaccatttgatgtgggttgcactcaagtctacttaggatagagtcacgtgaatgtctgtgactagcttatgcaaatatttaactttttaaaatgtttttgacttcaagtttgcaattgaaaaattttatgtaaataaattttttaaacag

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