LOCUS       NM_001433158            1530 bp    mRNA    linear   ROD 09-AUG-2024
DEFINITION  Rattus norvegicus ESX homeobox 1 (Esx1), mRNA.
ACCESSION   NM_001433158 XM_039100644
VERSION     NM_001433158.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1530)
  AUTHORS   Nishiyama,A., Xin,L., Sharov,A.A., Thomas,M., Mowrer,G., Meyers,E.,
            Piao,Y., Mehta,S., Yee,S., Nakatake,Y., Stagg,C., Sharova,L.,
            Correa-Cerro,L.S., Bassey,U., Hoang,H., Kim,E., Tapnio,R., Qian,Y.,
            Dudekula,D., Zalzman,M., Li,M., Falco,G., Yang,H.T., Lee,S.L.,
            Monti,M., Stanghellini,I., Islam,M.N., Nagaraja,R., Goldberg,I.,
            Wang,W., Longo,D.L., Schlessinger,D. and Ko,M.S.
  TITLE     Uncovering early response of gene regulatory networks in ESCs by
            systematic induction of transcription factors
  JOURNAL   Cell Stem Cell 5 (4), 420-433 (2009)
   PUBMED   19796622
REFERENCE   2  (bases 1 to 1530)
  AUTHORS   Yanagihara,M., Ishikawa,S., Naito,M., Nakajima,J., Aburatani,H. and
            Hatakeyama,M.
  TITLE     Paired-like homeoprotein ESXR1 acts as a sequence-specific
            transcriptional repressor of the human K-ras gene
  JOURNAL   Oncogene 24 (38), 5878-5887 (2005)
   PUBMED   15897875
REFERENCE   3  (bases 1 to 1530)
  AUTHORS   Ozawa,H., Ashizawa,S., Naito,M., Yanagihara,M., Ohnishi,N.,
            Maeda,T., Matsuda,Y., Jo,Y., Higashi,H., Kakita,A. and
            Hatakeyama,M.
  TITLE     Paired-like homeodomain protein ESXR1 possesses a cleavable
            C-terminal region that inhibits cyclin degradation
  JOURNAL   Oncogene 23 (39), 6590-6602 (2004)
   PUBMED   15235584
REFERENCE   4  (bases 1 to 1530)
  AUTHORS   Li,Y. and Behringer,R.R.
  TITLE     Esx1 is an X-chromosome-imprinted regulator of placental
            development and fetal growth
  JOURNAL   Nat Genet 20 (3), 309-311 (1998)
   PUBMED   9806555
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Aug 7, 2024 this sequence version replaced XM_039100644.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.32958.1,
                                           SRR26360181.921244.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000021.1  105246537-105246739 c
            204-329             JAXUCZ010000021.1  105246180-105246305 c
            330-897             JAXUCZ010000021.1  105243865-105244432 c
            898-943             JAXUCZ010000021.1  105243273-105243318 c
            944-1530            JAXUCZ010000021.1  105241568-105242154 c
FEATURES             Location/Qualifiers
     source          1..1530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..1530
                     /gene="Esx1"
                     /note="ESX homeobox 1"
                     /db_xref="GeneID:679219"
                     /db_xref="RGD:1590738"
     exon            1..203
                     /gene="Esx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1375
                     /gene="Esx1"
                     /note="homeobox protein ESX1"
                     /codon_start=1
                     /product="ESX homeobox 1"
                     /protein_id="NP_001420087.1"
                     /db_xref="GeneID:679219"
                     /db_xref="RGD:1590738"
                     /translation="

MESHKKCRCCYCTDLKNFAGAVKEETLEDPQPSLSSTLLEGANYQGNEEFETTYYSNFGDSQKEEEVEMETSLFNSMFLEETNYQEPKELEPASKEAAAPVAEAPRAWKGNENLGGGILESNAQLGEADATPMPQSLMRPLMQPVARSSLQPPLQSLPPNPLQLQLQPQPQPHPQSQPQPQPQPQLQPLPANLLQAPQQPEQQPQGQPQGQPQQQPQQQPQQQLQQQPKPRRYRISFTQIQLQELEAYFQRVQYPDLFARMELARRLGLPESRVQVWFQNRRAKWRRLRRAQAYRNMVPVAMGPPVGVFVDDHYGPIPVVEVIWKCYPMVPRPMHPQMMPLPPRGPPIFRMPLPFRPPPPPPFPWPPVPPEIHMPNAAMGFNPNPNPNPNPNPNPNPNPNPNPNPNPNGNVNSAGPRY"

     misc_feature    809..964
                     /gene="Esx1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            204..329
                     /gene="Esx1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..897
                     /gene="Esx1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..943
                     /gene="Esx1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1530
                     /gene="Esx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcactctggtgcaggagcagcagctggcaccacctctggtcccgacctcctcaccagctcggcagaagccgagaagtccgcaggagccagcgactcaacaacccacctcgctccagccatggaatctcacaaaaagtgccgctgctgctactgcactgacttgaagaactttgcaggagcagtgaaggaggaaacacttgaggatccacagcctagcttgagctcgacgcttttggagggagcaaactaccagggaaacgaggaatttgaaacaacttactactccaactttggagacagccagaaggaggaagaagtggagatggagacctctctgttcaactccatgtttctagaagaaacaaactaccaggaacccaaggaactcgaacccgcgagcaaagaagcagcagcacctgttgcagaagcaccacgagcctggaaggggaatgaaaatcttggaggcggcatcctggagtccaacgctcagctgggggaggcggatgccacccccatgccgcagtccctgatgcggcctctaatgcaacctgttgcacggtcttcgctgcagcccccgctgcaatccctgccgccaaacccgctgcagctccagctccagccgcagccccaaccccatccccagtcgcagccgcagccgcagccgcagccacagctgcagcccctgccggcaaacctgctgcaggccccgcagcagcccgagcagcagccccaggggcagccccaggggcagccccagcagcagcctcagcagcagccccagcagcagctccagcagcagccgaagccccgccgctaccgcatttccttcacgcagatccaactgcaggagttggaagcctatttccagcgcgttcagtacccggacctgtttgctcgaatggagcttgccagacgcctgggcttgcctgaatccagagttcaggtttggtttcagaacagaagggccaagtggagacgacttcggcgggcacaagcatatagaaacatggttccagtggctatgggtccccctgttggtgtattcgttgatgatcattatggtcccatccctgttgtggaggttatttggaaatgttaccctatggtgccgcgtcccatgcaccctcaaatgatgcctcttccacccaggggccctccaatattcagaatgcctctaccatttaggccaccccctccacctccatttccatggccacctgtaccacccgagatccacatgcccaatgcagcgatgggttttaaccccaaccccaatcccaaccccaaccccaaccccaatcccaaccccaaccccaaccccaaccccaatcccaaccccaacggaaatgtcaattctgcgggtcctagatactgaagtctacatcagttttctcaaagtgtttttcagccagatttatgttgtttgtagacactataagcattactcattacataggtgttaaatgaaattatgtgcaaagttaatgccttctttgttatgattttcaataaaagtttggattagcagca

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